Indication and Usage
Glucagon is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes.

Do not use Glucagon if:

• you have a tumor in the gland on top of your kidneys (adrenal gland) called a pheochromocytoma.
• you have a tumor in your pancreas called an insulinoma.
• you are allergic to glucagon or lactose or any of the ingredients in Glucagon.

Before using Glucagon, tell your doctor about all of your medical conditions, including if you:

• have kidney problems.
• have pancreas problems.
• have not had food or water for a long time (prolonged fasting or starvation).
• have low blood sugar that does not go away (chronic hypoglycemia).
• have heart problems.
• are pregnant or plan to become pregnant. It is not known if Glucagon will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if Glucagon passes into your breast milk.

Tell your doctor about all the medicines you take,
including prescription and over-the-counter medicines, vitamins and herbal supplements. Glucagon may affect the way other medicines work, and other medicines may affect how Glucagon works. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When using Glucagon, you should:

• Read the detailed Instructions for Use that come with Glucagon.
• Use Glucagon exactly as your doctor tells you to.
• Make sure that you and your family know how to use Glucagon the right way before you need it.
• Act quickly. Having very low blood sugar for a period of time may be harmful.
• Call for emergency medical help right after you use Glucagon.
• If the person does not respond after 15 minutes, another dose may be given, if available.
• Eat sugar or a sugar-sweetened product such as a regular soft drink or fruit juice as soon as you are able to swallow.
• Tell your doctor each time you use Glucagon. Your doctor may need to change the dose of your diabetes medicines.

Glucagon may cause serious side effects, including:

• High blood pressure. Glucagon can cause high blood pressure in certain people with tumors in their adrenal glands.
• Low blood sugar. Glucagon can cause low blood sugar in patients with tumors in their pancreas called insulinomas and glucagonomas by making too much insulin in their bodies.
• Serious allergic reactions. Call your doctor or get medical help right away if you have a serious allergic reaction including rash, difficulty breathing, or low blood pressure.

The most common side effects of Glucagon include:

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Glucagon. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

This Important Safety Information does not include all the information needed to use Glucagon for Injection safely and effectively. To learn more about Glucagon for Injection, talk to your doctor or pharmacist. Please see the full prescribing information for Glucagon for Injection and Patient Information. The full prescribing information is also available at www.fresenius-kabi.com/us.

Indication and Usage
Glucagon for Injection is an antihypoglycemic agent indicated for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes.

Important Safety Information
Glucagon for Injection is contraindicated in patients with pheochromocytoma, insulinoma, or a known hypersensitivity to glucagon or any of the excipients.

Catecholamine Release in Patients with Pheochromocytoma: Glucagon for Injection is contraindicated in patients with pheochromocytoma because Glucagon for Injection may stimulate the release of catecholamines from the tumor.

Hypoglycemia in Patients with Insulinoma: In patients with insulinoma, administration may produce an initial increase in blood glucose; however, Glucagon for Injection may stimulate exaggerated insulin release from an insulinoma and cause hypoglycemia. If a patient develops symptoms of hypoglycemia after a dose of Glucagon for Injection, give glucose orally or intravenously.

Hypersensitivity and Allergic Reactions: Allergic reactions have been reported and include generalized rash, and in some cases anaphylactic shock with breathing difficulties, and hypotension.

Lack of Efficacy in Patients with Decreased Hepatic Glycogen: Glucagon for Injection is effective in treating hypoglycemia only if sufficient hepatic glycogen is present. Patients in states of starvation, with adrenal insufficiency or chronic hypoglycemia may not have adequate levels of hepatic glycogen for Glucagon for Injection to be effective. Patients with these conditions should be treated with glucose.

Necrolytic Migratory Erythema (NME): a skin rash, has been reported postmarketing following continuous glucagon infusion and resolved with discontinuation of the glucagon. Should NME occur, consider whether the benefits of continuous glucagon infusion outweigh the risks.

Most common adverse reactions (>5% or greater incidence): Injection site swelling, injection site erythema, vomiting, nausea, decreased blood pressure, asthenia, headache, dizziness, pallor, diarrhea, and somnolence.

To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176, option 5, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Beta-blockers: Patients taking beta-blockers may have a transient increase in pulse and blood pressure.

Indomethacin: In patients taking indomethacin Glucagon for Injection may lose its ability to raise glucose or may produce hypoglycemia.

Warfarin: Glucagon for Injection may increase the anticoagulant effect of warfarin.

This Important Safety Information does not include all the information needed to use Glucagon for Injection safely and effectively. Please see the full prescribing information for Glucagon for Injection and Patient Information. The full prescribing information is also available at www.fresenius-kabi.com/us.